张娟 博士

履历(教育及工作经验)

教育：

1. 2011 中国安徽中医药大学药学学士
2. 2015 中国云南中医药大学中药学硕士
3. 2019 中国上海中医药大学中药学博士

工作经验：

1. 2020至今 博士后研究员 香港中文大学中医学院
2. 2019-2020 研究助理 香港中文大学中医学院

科研范围

1. 中药及其活性成分抗肿瘤作用（肿瘤细胞凋亡、自噬、转移、耐药和防止肿瘤复发）机理研究及抗肿瘤小分子药物开发

著作及论文（选列）：

1. Xian YF*, Zhang J*, Bian ZX, Zhou H, Zhang ZB, Lin ZX, Xu HX. Bioactive natural compounds against human coronaviruses: a review and perspective. Acta Pharm Sin B, (2020)10(7):1163-1174. (Co-first author)
2. Han L, Xu DQ, Xi ZC, Wu M, Wan Najbah Nik Nabil, Zhang J, Xu HX, et al. The natural compound Oblongifolin C exhibits anticancer activity by inhibiting HSPA8 and Cathepsin B in vitro. Frontiers in pharmacology, (2020)11:564833
3. Ye Y, Wu M, Lao YZ, Fu W, Yang X, Zhang J, Xu HX, Xu G. Dearomatized Isoprenylated Acylphloroglucinol Derivatives with Potential Antitumor Activities from Hypericum henryi. Nat Prod Bioprospect, (2020)10(1):1-11.
4. Zhang J, Zheng Z, Wu M, Lao Y, Xu H, et al. The natural compound neobractatin inhibits tumor metastasis by upregulating RNA-binding-protein MBNL2, Cell Death & Disease, (2019)10:554.
5. Zheng Z, Wu M, Zhang J, Fu W, Xu N, Lao YZ, Xu HX. The natural compound neobractatin induces cell cycle arrest by regulating E2F1 and GADD45α. Frontiers in oncology, (2019) 9: 654.
6. Yuan M, Xu L, Zhang J, Kong S, Wu M, Lao YZ, Xu HX. SRC and MEK co-inhibition synergistically enhances the anti-tumor effect in both NSCLC and erlotinib resistant NSCLC cells. Frontiers in oncology, (2019) 9: 586.
7. Duan Y*, Zhang J*, et al. Spirocyclic polycyclic polyprenylated acylphloroglucinols from the ethyl acetate fraction of Hypericum henryi, Tetrahedron Letters, 2018, 59 (2018): 4067–4072 (Co-first author)