Dr. Ip Siu Po Paul

Resume (Education and Working Experience)

Education：

1. 1993 Bachelor of Science (Hons.),Department of Biochemistry, The Chinese University of Hong Kong
2. 1998 Doctor of Philosophy, Department of Biochemistry, The Hong Kong University of Science and Technology

Working Experience：

1. 1998-2000 Croucher Foundation Postdoctoral Fellow
2. 2001 Postdoctoral Fellow, SCM, CUHK
3. 2002-2006 Scientific Officer, SCM, CUHK
4. 2006-2009 Research Assistant Professor, SCM, CUHK
5. 2009-2017 Research Fellow, SCM, CUHK
6. 2017- Present Senior Research Fellow, SCM, CUHK

Teaching (Courses)

1. BCME5112 Pharmacology and toxicology of Chinese Medicines, The Chinese University of Hong Kong
2. BCME4106 Tutorial in Chinese Medicine (Current Literature of Chinese Medicine and Management of Information), The Chinese University of Hong Kong
3. BCME5102 Authentication of Chinese Medicinal Materials, The Chinese University of Hong Kong
4. Certificate Programme in Authentication of Chinese Materia Medica (funded by Innovation and Technology Commission), The Chinese University of Hong Kong

Research Interest

1. Pharmacological study of herbal medicine
2. Chemical standardization and quality control of herbal materials
3. Service on chemical analysis of herbal medicine
4. Advisory services for registration of proprietary Chinese medicines

Selected Publications

1. Zhao J, Niu X, Yu J, Xiao X, Li W, Zang L, Hu Z, Siu-Po Ip P, Li W. Poria cocos polysaccharides attenuated ox-LDL-induced inflammation and oxidative stress via ERK activated Nrf2/HO-1 signaling pathway and inhibited foam cell formation in VSMCs. Int Immunopharmacol 2020;80:106173. DOI:10.1016/j.intimp.2019.106173.
2. Xian YF, Ip SP, Li HQ, Qu C, Su ZR, Chen JN, Lin ZX. Isorhynchophylline exerts antidepressant-like effects in mice via modulating neuroinflammation and neurotrophins: involvement of the PI3K/Akt/GSK-3β signaling pathway. FASEB J 2019;33(9):10393-408. DOI:10.1096/fj.201802743RR.
3. Xian YF, Hu Z, Ip SP, Chen JN, Su ZR, Lai XP, Lin ZX. Comparison of the anti-inflammatory effects of Sinapis alba and Brassica juncea in mouse models of inflammation. Phytomedicine 2018;50:196-204. DOI:10.1016/j.phymed.2018.05.010.
4. Lai ZQ, Ip SP, Liao HJ, Lu Z, Xie JH, Su ZR, Chen YL, Xian YF, Leung PS, Lin ZX. Brucein D, a Naturally Occurring Tetracyclic Triterpene Quassinoid, Induces Apoptosis in Pancreatic Cancer through ROS-Associated PI3K/Akt Signaling Pathway. Front Pharmacol 2017;8:936. DOI:10.3389/fphar.2017.00936.
5. Mao QQ, Huang Z, Zhong XM, Xian YF, Ip SP*. Brain-derived neurotrophic factor signalling mediates the antidepressant-like effect of piperine in chronically stressed mice. Behav Brain Res 2014;261:140-5. DOI:10.1016/j.bbr.2013.12.020.
6. Yang JM, Xian YF, Ip PS, Wu JC, Lao L, Fong HH, Sung JJ, Berman B, Yeung JH, Che CT. Schisandra chinensis reverses visceral hypersensitivity in a neonatal-maternal separated rat model. Phytomedicine 2012;19(5):402-8. DOI:10.1016/j.phymed.2011.11.013.
7. Tjong Y, Ip S, Lao L, Fong HH, Sung JJ, Berman B, Che C. Analgesic effect of Coptis chinensis rhizomes (Coptidis Rhizoma) extract on rat model of irritable bowel syndrome. J Ethnopharmacol 2011;135(3):754-61. DOI:10.1016/j.jep.2011.04.007.
8. Ip SP, Zhao M, Xian Y, Chen M, Zong Y, Tjong YW, Tsai SH, Sung JJ, Bensoussan A, Berman B, Fong HH, Che CT. Quality assurance for Chinese herbal formulae: standardization of IBS-20, a 20-herb preparation. Chin Med 2010;5:8. DOI:10.1186/1749-8546-5-8.
9. Mao QQ, Xian YF, Ip SP*, Che CT. Involvement of serotonergic system in the antidepressant-like effect of piperine. Prog Neuropsychopharmacol Biol Psychiatry 2011;35(4):1144-7. DOI:10.1016/j.pnpbp.2011.03.017.
10. Chen Y, Ip SP*, Ko KM, Poon TC, Ng EW, Lai PB, Mao QQ, Xian YF, Che CT. A proteomic approach in investigating the hepatoprotective mechanism of Schisandrin B: role of raf kinase inhibitor protein. J Proteome Res 2011;10(1):299-304. DOI:10.1021/pr100871h.