Resume (Education and Working Experience)

Education：

1. BSc in Medical Science (TCM, Guangzhou University of TCM, 1987)
2. PhD in Pharmacognosy (King’s College London, 1999)

Working Experience：

1. 1987-1990 Medical Doctor, the Affiliated Hospital of Guangdong Provincial Research Institute of TCM, China.
2. 1991 - 1998 Herbalist and acupuncturist, Institute of Chinese Medicine, London, UK
3. 1998 - 2002 Senior Lecturer, School of Health and Social Science, Middlesex University, London, UK
4. 2002 - 2003 Assistant Professor, Macau University of Science and Technology, Macau
5. 2003 - 2010 Assistant Professor, School of Chinese Medicine, CUHK
6. 2010 - 2020 Associate Professor, School of Chinese Medicine, CUHK
7. Start from 2017 Associate Director, School of Chinese Medicine, CUHK
8. Start from 2017 Director, Hong Kong Institute of Integrative Medicine
9. Start from 2020 Professor, School of Chinese Medicine, CUHK

Teaching (Courses)

1. BCME2001 Methodologies of Diagnosis in Chinese Medicine
2. BCME3110 Surgery and Topical Diseases in Chinese Medicine
3. BCME5020 Diagnostic Approaches in Chinese Medicine Practice
4. BCME6502 Diagnosis in Chinese Medicine
5. BCME6506 Research Methodologies in Acupuncture
6. BCME6510 Research Project in Acupuncture and Essay Writing
7. UGEB2831 Fundamentals in Chinese Medicine
8. Coursera “Everyday Chinese Medicine”
   https://www.coursera.org/learn/everyday-chinese-medicine

Expertise

1. Chinese medicine (Clinical practice)
2. Clinical trials on Chinese medicine
3. Pharmacology of Chinese medicine

Research Interest

1. R & D on Chinese medicines for the treatment of pancreatic cancer, prostate cancer, Alzheimer’s disease, Parkinson’s disease, psoriasis and atopic dermatitis
2. Clinical trials on the effectiveness and safety of Chinese medical interventions, including (1) acupuncture for overactive bladder in elderly; (2) an innovative Chinese herbal formula for atopic dermatitis; (3) Chinese herb Gou-teng for mild cognitive impairment; (4) modified Wu-Zi-Yan-Zong-Wan for male infertility; and (5) a Chinese herbal prescription for leg cramp in elderly.
3. Pharmacological evaluations using in vitro and in vivo models on herb-drug interactions between Chinese medicines and pharmaceuticals in the areas of hyperthyroidism and prostate cancer.
4. Phytochemical studies of Chinese medicines.
5. Literature reviews using systematic review and meta-analysis approaches on the effectiveness and safety of Chinese medical interventions including herbal medicine and acupuncture & moxibustion.

Selected Publications

1. Qu C, Li QP, Su ZR, Ip SP, Yuan QJ, Xie YL, Xu QQ, Yang W, Huang YF, Xian YF, Lin ZX*. Nano-Honokiol Ameliorates the Cognitive Deficits in TgCRND8 Mice of Alzheimer's Disease via Inhibiting Neuropathology and Modulating Gut Microbiota. J Adv Res. 2021 Mar 31. DOI:10.1016/j.jare.2021.03.012. Online ahead of print.
2. Zhang ZB, Ip SP, Cho WCS, Ng ACF, Hu Z, Huang YF, Luo DD, Xian YF, Lin ZX*. Herb-drug interactions between androgenic Chinese herbal medicines and androgen receptor antagonist on tumor growth: Studies on two xenograft prostate cancer animal models. Phytother Res. 2021 Jan 13. DOI:10.1002/ptr.7020. Online ahead of print.
3. Chen Y, Xian YF, Loo S, Chan WY, Liu L, Lin ZX*. Anti-atopic dermatitis effects of dictamni cortex: Studies on in vitro and in vivo experimental models. Phytomedicine 2021;82:153453. DOI:10.1016/j.phymed.2020.153453.
4. Yang W, Liu Y, Xu QQ, Xian YF, Lin ZX*. Sulforaphene Ameliorates Neuroinflammation and Hyperphosphorylated Tau Protein via Regulating the PI3K/Akt/GSK-3β Pathway in Experimental Models of Alzheimer's Disease. Oxid Med Cell Longev 2020;2020:4754195. DOI:10.1155/2020/4754195.
5. Yuan Q, Xian YF, Huang YF, Wu W, Song YQ, Lin ZX*. Intracisternal injection of beta-amyloid seeds promotes cerebral amyloid angiopathy. Brain Behav Immun 2020;89:628-40. DOI:10.1016/j.bbi.2020.07.038.
6. Xian YF, Qu C, Liu Y, Ip SP, Yuan QJ, Yang W, Lin ZX*. Magnolol Ameliorates Behavioral Impairments and Neuropathology in a Transgenic Mouse Model of Alzheimer's Disease. Oxid Med Cell Longev 2020;2020:5920476. DOI:10.1155/2020/5920476.
7. Xian Y, Zhang J, Bian Z, Zhou H, Zhang Z, Lin Z*, Xu H. Bioactive natural compounds against human coronaviruses: a review and perspective. Acta Pharm Sin B 2020;10(7):1163-74. DOI:10.1016/j.apsb.2020.06.002.
8. Li HQ, Ip SP, Yuan QJ, Zheng GQ, Tsim KKW, Dong TTX, Lin G, Han Y, Liu Y, Xian YF, Lin ZX*. Isorhynchophylline ameliorates cognitive impairment via modulating amyloid pathology, tau hyperphosphorylation and neuroinflammation: Studies in a transgenic mouse model of Alzheimer's disease. Brain Behav Immun 2019;82:264-78. DOI:10.1016/j.bbi.2019.08.194.
9. Zhang X, Liu XD, Xian YF, Zhang F, Huang PY, Tang Y, Yuan QJ, Lin ZX*. Berberine enhances survival and axonal regeneration of motoneurons following spinal root avulsion and re-implantation in rats. Free Radic Biol Med 2019;143:454-70. DOI:10.1016/j.freeradbiomed.2019.08.029.
10. Xian YF, Ip SP, Li HQ, Qu C, Su ZR, Chen JN, Lin ZX*. Isorhynchophylline exerts antidepressant-like effects in mice via modulating neuroinflammation and neurotrophins: involvement of the PI3K/Akt/GSK-3β signaling pathway. FASEB J 2019;33(9):10393-408. DOI:10.1096/fj.201802743RR.

*Corresponding author