Resume (Education and Working Experience)

Education:

1. 1997 B.Med., Henan University of Traditional Chinese Medicine, China (Chinese Medicine)
2. 2000 M.Med., Chengdu University of Traditional Chinese Medicine, China (Internal Medicine in Chinese Medicine)
3. 2003 M.D., Shanghai University of Traditional Chinese Medicine, China (Internal Medicine in Chinese Medicine)

Working Experience:

1. 2003-2005 Physician-in-charge, Shanghai Clinical Centre of Cardiovascular & Cerebrovascular Diseases in Traditional Chinese Medicine, Shanghai Tenth People’s Hospital, Tongji University, Shanghai, China
2. 2006-2008 Postdoctoral Research Fellow, Department of Rehabilitation Sciences, Hong Kong Polytechnic University, Hong Kong
3. 2008-2009 Postdoctoral Research Fellow, Department of Physiology, University of Sydney, Australia
4. 2009-2010 Research Associate, Department of Rehabilitation Sciences, Hong Kong Polytechnic University, Hong Kong
5. 2011-2011 Research Associate, Department of Orthopaedics & Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong
6. 2011-2017 Assistant Professor, School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong
7. 2017-2023 Associate Professor, School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong
8. 2018-2022 Assistant Director, School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong
9. 2022-now Associate Director, School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong
10. Start from 1-Aug,2023 Professor, School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong

Teaching (Courses)

1. BCME3102 Internal Medicine I
2. BCME3202 Internal Medicine II
3. BCME3208 Hong Kong Medical System
4. BCME4107 Ent and Ophthalmology
5. BCME4200 Research Methodologies in Chinese Medicine
6. BCME5405 Internal Medicine (Chinese Medicine) I
7. BCME5505 Internal Medicine (Chinese Medicine) II
8. BCME6125 Selected Ancient Readings on Chinese Medicine
9. BCME6160 Current Research Methodologies in Chinese Medicine and Thesis
10. BCME6506 Research Methodologies in Acupuncture
11. BCME6507 Seminars on Chinese Medicine
12. BCME6510 Research Project in Acupuncture and Essay Writing

Research Interest

1. Musculoskeletal diseases (Muscle atrophic diseases, metabolic bone diseases) (Focused on mechanistic exploration of protein-small molecule interaction, discovery of natural product lead compounds and targeted drug delivery modification in recent 10 years.)
2. Cardio-cerebral diseases (Atherosclerotic diseases)
3. Pulmonary disease (Pneumoconiosis, pulmonary fibrosis)
4. Cancer (Ovarian cancer, breast cancer and osteosarcoma)

Selected Publications

1. Chen Z, Zhang N, Chu HY, Yu Y, Zhang ZK, Zhang G, Zhang BT*. Connective Tissue Growth Factor: From Molecular Understandings to Drug Discovery. Front Cell Dev Biol 2020;8:593269. DOI:10.3389/fcell.2020.593269. (Impact factor 2020: 6.684)
2. Ni S, Zhuo Z, Pan Y, Yu Y, Li F, Liu J, Wang L, Wu X, Li D, Wan Y, Zhang L, Yang Z, Zhang BT*, Lu A, Zhang G. Recent Progress in Aptamer Discoveries and Modifications for Therapeutic Applications. ACS Appl Mater Interfaces 2021;13(8):9500-19. DOI:10.1021/acsami.0c05750. (Impact factor 2020: 9.229)
3. Zhang N, Chen Z, Liu D, Jiang H, Zhang ZK, Lu A, Zhang BT*, Yu Y, Zhang G. Structural Biology for the Molecular Insight between Aptamers and Target Proteins. Int J Mol Sci 2021;22(8):4093. DOI:10.3390/ijms22084093. (Impact factor 2020: 5.923)
4. Zhuo Z, Wan Y, Guan D, Ni S, Wang L, Zhang Z, Liu J, Liang C, Yu Y, Lu A, Zhang G, Zhang BT*. A Loop-Based and AGO-Incorporated Virtual Screening Model Targeting AGO-Mediated miRNA-mRNA Interactions for Drug Discovery to Rescue Bone Phenotype in Genetically Modified Mice. Adv Sci (Weinh) 2020;7(13):1903451. DOI:10.1002/advs.201903451. (Impact factor 2020: 16.806)
5. Liang C, Li J, Lu C, Xie D, Liu J, Zhong C, Wu X, Dai R, Zhang H, Guan D, Guo B, He B, Li F, He X, Zhang W, Zhang BT*, Zhang G, Lu A. HIF1α inhibition facilitates Leflunomide-AHR-CRP signaling to attenuate bone erosion in CRP-aberrant rheumatoid arthritis. Nat Commun 2019;10(1):4579. DOI:10.1038/s41467-019-12163-z. (Impact factor 2020: 14.919)
6. Liang C, Peng S, Li J, Lu J, Guan D, Jiang F, Lu C, Li F, He X, Zhu H, Au DWT, Yang D, Zhang BT*, Lu A, Zhang G. Inhibition of osteoblastic Smurf1 promotes bone formation in mouse models of distinctive age-related osteoporosis. Nat Commun 2018;9(1):3428. DOI:10.1038/s41467-018-05974-z. (Impact factor 2020: 14.919)
7. Zhang ZK, Li J, Guan D, Liang C, Zhuo Z, Liu J, Lu A, Zhang G, Zhang BT*. Long Noncoding RNA lncMUMA Reverses Established Skeletal Muscle Atrophy following Mechanical Unloading. Mol Ther 2018;26(11):2669-80. DOI:10.1016/j.ymthe.2018.09.014. (Impact factor 2020: 11.454)
8. Zhang ZK, Li J, Guan D, Liang C, Zhuo Z, Liu J, Lu A, Zhang G, Zhang BT*. A newly identified lncRNA MAR1 acts as a miR-487b sponge to promote skeletal muscle differentiation and regeneration. J Cachexia Sarcopenia Muscle 2018;9(3):613-26. DOI:10.1002/jcsm.12281. (Impact factor 2020: 12.910)
9. Li F, Lu J, Liu J, Liang C, Wang M, Wang L, Li D, Yao H, Zhang Q, Wen J, Zhang ZK, Li J, Lv Q, He X, Guo B, Guan D, Yu Y, Dang L, Wu X, Li Y, Chen G, Jiang F, Sun S, Zhang BT*, Lu A, Zhang G. A water-soluble nucleolin aptamer-paclitaxel conjugate for tumor-specific targeting in ovarian cancer. Nat Commun 2017;8(1):1390. DOI:10.1038/s41467-017-01565-6. (Impact factor 2020: 14.919)
10. Liang C, Guo B, Wu H, Shao N, Li D, Liu J, Dang L, Wang C, Li H, Li S, Lau WK, Cao Y, Yang Z, Lu C, He X, Au DW, Pan X, Zhang BT, Lu C, Zhang H, Yue K, Qian A, Shang P, Xu J, Xiao L, Bian Z, Tan W, Liang Z, He F, Zhang L, Lu A, Zhang G. Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNA interference-based bone anabolic strategy. Nat Med 2015;21(3):288-94. DOI:10.1038/nm.3791. (Impact factor 2020: 53.440)

 *Corresponding author