Prof. Lin Zhixiu

Prof. Lin Zhixiu

Position Associate Director
Office Room 101-D, Li Wai Chun Building, Chung Chi College, The Chinese University of Hong Kong, Hong Kong
Tel. (852) 3943 6347
Fax. (852) 3942 0941
Email This email address is being protected from spambots. You need JavaScript enabled to view it.

 


Resume (Education and Working Experience)

Education:

  1. BSc in Medical Science (TCM, Guangzhou University of TCM, 1987)
  2. PhD in Pharmacognosy (King’s College London, 1999)

Working Experience:

  1. 1987-1990 Medical Doctor, the Affiliated Hospital of Guangdong Provincial Research Institute of TCM, China.
  2. 1991 - 1998 Herbalist and acupuncturist, Institute of Chinese Medicine, London, UK
  3. 1998 - 2002 Senior Lecturer, School of Health and Social Science, Middlesex University, London, UK
  4. 2002 - 2003 Assistant Professor, Macau University of Science and Technology, Macau
  5. 2003 - 2010 Assistant Professor, School of Chinese Medicine, CUHK
  6. 2010 - 2020 Associate Professor, School of Chinese Medicine, CUHK
  7. Start from 2017 Associate Director, School of Chinese Medicine, CUHK
  8. Start from 2017 Director, Hong Kong Institute of Integrative Medicine
  9. Start from 2020 Professor, School of Chinese Medicine, CUHK
  

Teaching (Courses)

  1. BCME2001 Methodologies of Diagnosis in Chinese Medicine
  2. BCME3110 Surgery and Topical Diseases in Chinese Medicine
  3. BCME5020 Diagnostic Approaches in Chinese Medicine Practice
  4. BCME6502 Diagnosis in Chinese Medicine
  5. BCME6506 Research Methodologies in Acupuncture
  6. BCME6510 Research Project in Acupuncture and Essay Writing
  7. UGEB2831 Fundamentals in Chinese Medicine
  8. Coursera “Everyday Chinese Medicine”
    https://www.coursera.org/learn/everyday-chinese-medicine

Expertise

  1. Chinese medicine (Clinical practice)
  2. Clinical trials on Chinese medicine
  3. Pharmacology of Chinese medicine

Research Interest

  1. Research and drug development of Chinese medicines for the treatment of pancreatic cancer, Alzheimer’s disease, Parkinson’s disease, psoriasis and atopic dermatitis
  2. Clinical trials on the effectiveness and safety of Chinese medical interventions, including (1) acupuncture for post-stroke dysphagia; (2) acupuncture for overactive bladder in elderly; (3) topical preparation containing Rubiae Radix for plaque type of psoriasis; and (4) herbal prescriptions for atopic dermatitis
  3. Pharmacological evaluations using in vitro and in vivo models on herb-drug interactions between Chinese medicines and pharmaceuticals in the areas of lung cancer, stroke and diabetes mellitus
  4. Phytochemistry of Chinese medicines
  5. Literature reviews using systematic review and meta-analysis approach on the effectiveness and safety of Chinese medical interventions including herbal medicine and acupuncture & moxibustion

Selected Publications

  1. Lai ZQ, Ip SP, Liao HJ, Lu Z, Xie JH, Su ZR, Chen YL, Xian YF, Leung PS, Lin ZX*. Brucein D, a Naturally Occurring Tetracyclic Triterpene Quassinoid, Induces Apoptosis in Pancreatic Cancer through ROS-Associated PI3K/Akt Signaling Pathway. Front Pharmacol. 2017;8:936.
  2. Yuan Q, Yang J, Wu W, Lin ZX*. Motor deficits are independent of axonopathy in an Alzheimer's disease mouse model of TgCRND8 mice. Oncotarget. 2017 Jun 9. doi: 10.18632/oncotarget.18429
  3. Fan ZM, Wang DY, Yang JM, Lin ZX, Lin YX, Yang AL, Fan H, Cao M, Yuan SY, Liu ZJ, Zhou X, Wang YH. Dalbergia odorifera extract promotes angiogenesis through upregulation of VEGFRs and PI3K/MAPK signaling pathways. J Ethnopharmacol. 2017;204:132-141.
  4. Lu Z, Lai ZQ, Leung AWN, Leung PS, Li ZS, Lin ZX. Exploring brusatol as a new anti-pancreatic cancer adjuvant: biological evaluation and mechanistic studies. Oncotarget. 2017 May 10. doi: 10.18632/oncotarget.17761.
  5. Lu Z, Lai ZQ, Leung AWN, Leung PS, Li ZS, Lin ZX*. Exploring brusatol as a new anti-pancreatic cancer adjuvant: biological evaluation and mechanistic studies. Oncotarget. 2017 May 10. doi: 10.18632/oncotarget.17761.
  6. Xian YF, Ip SP, Mao QQ, Lin ZX*. Neuroprotective Effects of Honokiol against Beta-Amyloid-Induced Neurotoxicity via GSK-3β and β-Catenin Signaling Pathway in PC12 Cells. Neurochem Int. 2016;97:8-14.
  7. Li X, Lao YZ, Zhang H, Wang XY, Tan HS, Lin ZX, Xu HX. The natural compound Guttiferone F sensitizes prostate cancer to starvation induced apoptosis via calcium and JNK elevation. BMC Cancer. 2015;15:254. doi: 10.1186/s12885-015-1292-z.
  8. Wu M, Lao Y, Xu N, Wang X, Tan H, Fu W, Lin ZX, Xu H. Guttiferone K induces autophagy and sensitizes cancer cells to nutrient stress-induced cell death. Phytomedicine. 2015;15;22(10):902-10.
  9. Chan K, Zhang HW, Lin ZX. An Overview on Adverse Drug Reactions to Traditional Chinese Medicines. Br J Clin Pharmacol 2015;80(4):834-43.
  10. Olayanju A, Copple IM, Bryan HK, Edge GT, Sison RL, Wong MW, Lai ZQ, Lin ZX, Dunn K, Sanderson CM, Alghanem AF, Cross MJ, Ellis EC, Ingelman-Sundberg M, Malik HZ, Kitteringham NR, Goldring CE, Park BK. Brusatol Provokes a Rapid and Transient Inhibition of Nrf2 Signalling and Sensitizes Mammalian Cells to Chemical Toxicity - Implications for Therapeutic Targeting of Nrf2. Free Radical Biol Med. 2015;78:202-12.


*Corresponding author

 

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